Diffuse brain infiltration by tumor cells is a hallmark of glioma. Molecular mechanisms of brain invasion are poorly understood due to the difficulty to model this process in culture. A new study published in Cell Reports developed a three-dimensional organotypic model and identified interferon regulatory factor 3 (IRF3) as repressor of glioma invasion.

中文翻译：

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在3D-Organotypic模型中解剖胶质瘤侵袭性

肿瘤细胞对脑的弥漫性浸润是神经胶质瘤的标志。由于难以在培养中对这一过程进行建模，因此人们对大脑入侵的分子机制了解甚少。发表在《细胞报告》上的一项新研究开发了三维器官模型，并确定了干扰素调节因子3（IRF3）作为神经胶质瘤侵袭的阻遏物。