The biochemical properties of the signal-induced multifunctional transcription factor II-I (TFII-I) indicate that it is involved in a variety of gene regulatory processes. Although gene ablation in murine models and cell-based assays show that it is encoded by an essential gene, GTF2I/Gtf2i, its physiologic role in human disorders was relatively unknown until recently. Novel studies show that it is involved in an array of human diseases including neurocognitive disorders, systemic lupus erythematosus (SLE), and cancer. Here I bring together these diverse observations to illustrate its multiple pathophysiologic functions and further conjecture on how these could be related to its known biochemical properties. I expect that a better understanding of these ‘structure–function’ relationships would lead to future diagnostic and/or therapeutic potential.

信号诱导的多功能转录因子II-I（TFII-I）的生化特性表明，它参与了多种基因调控过程。尽管在小鼠模型和基于细胞的实验中发现基因消融表明它是由必需基因GTF2I / Gtf2i编码的直到最近，它在人类疾病中的生理作用还是相对未知的。新颖的研究表明，它与一系列人类疾病有关，包括神经认知障碍，系统性红斑狼疮（SLE）和癌症。在这里，我汇集了这些不同的观察结果，以说明其多种病理生理功能，并进一步推测这些功能如何与其已知的生化特性有关。我希望对这些“结构-功能”关系有更好的了解会带来未来的诊断和/或治疗潜力。