The circadian clock directs many aspects of metabolism, to separate in time opposing metabolic pathways and optimize metabolic efficiency. The master circadian clock of the suprachiasmatic nucleus synchronizes to light, while environmental cues such as temperature and feeding, out of phase with the light schedule, may synchronize peripheral clocks. This misalignment of central and peripheral clocks may be involved in the development of disease and the acceleration of aging, possibly in a gender-specific manner. Here we discuss the interplay between the circadian clock and metabolism, the importance of the microbiome, and how they relate to aging.

中文翻译：

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昼夜节律时钟和新陈代谢：对微生物组和衰老的影响

生物钟指导新陈代谢的许多方面，及时分离相反的代谢途径并优化代谢效率。视交叉上核的主生物钟与光同步，而温度和进食等环境线索与光时间表异相，可能会同步外围时钟。中枢和外周时钟的这种失调可能与疾病的发展和衰老的加速有关，可能以性别特异性的方式发生。在这里，我们讨论生物钟和新陈代谢之间的相互作用、微生物组的重要性以及它们与衰老的关系。