Recent findings from a prospective clinical study involving multiregion whole-exome sequencing suggest that driver mutations in cancer-relevant genes including EGFR and TP53 are often clonal and precede whole-genome duplication events in early lung carcinogenesis. This paves an expressway to extensive subclonal diversification, elevated intratumoral heterogeneity, and dismal disease outcome.

中文翻译：

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在四车道高速公路上开车去癌症

一项涉及多区域全外显子组测序的前瞻性临床研究的最新发现表明，与癌症相关的基因（包括EGFR和TP53）中的驱动基因突变通常是克隆的，并且早于全基因组复制发生在肺癌早期。这为广泛的亚克隆多样化，肿瘤内异质性增加和疾病后果惨淡铺平了道路。