Infections have been a major cause of disease throughout the history of humans on earth. With the introduction of antibiotics, it was thought that infections had been conquered. However, bacteria have been able to develop resistance to antibiotics at an exponentially increasing rate. The growing threat from multi-drug resistant organisms calls for intensive action to prevent the emergence of totally resistant and untreatable infections. Novel, non-invasive, non-antibiotic strategies are needed that act more efficiently and faster than current antibiotics. One promising alternative is antimicrobial photodynamic inactivation (APDI), an approach that produces reactive oxygen species when dyes and light are combined. So far, it has been questionable if bacteria can develop resistance against APDI. This review paper gives an overview of recent studies concerning the susceptibility of bacteria towards oxidative stress, and suggests possible mechanisms of the development of APDI-resistance that should at least be addressed. Some ways to potentiate APDI and also to overcome future resistance are suggested.

在整个地球上的人类历史上，感染一直是疾病的主要诱因。随着抗生素的引入，人们认为感染已被克服。但是，细菌已经能够以指数级增长的速度发展出对抗生素的抗性。来自多重耐药性生物的日益增长的威胁要求采取强有力的行动，以防止出现完全耐药和无法治愈的感染。需要比目前的抗生素更有效和更快地起作用的新颖的，非侵入性的，非抗生素的策略。一种有希望的替代方法是抗菌光动力学灭活（APDI），一种在染料和光结合时产生活性氧的方法。迄今为止，细菌是否可以对APDI产生抗药性还存在疑问。这篇综述文章概述了有关细菌对氧化应激敏感性的最新研究，并提出了至少应解决的APDI抗性发展的可能机制。提出了增强APDI以及克服未来阻力的一些方法。