Trends in Microbiology ( IF 14.0 ) Pub Date : 2017-07-17 , DOI: 10.1016/j.tim.2017.06.006 Jessica Galloway-Peña 1 , Chelcy Brumlow 1 , Samuel Shelburne 2
Patients being treated for cancer are at high risk for infectious complications, generally due to colonizing organisms that gain access to sterile sites via disrupted epithelial barriers. There is an emerging understanding that the ability of bacterial pathogens, including multidrug-resistant organisms, to colonize and subsequently infect humans is largely dependent on protective bacterial species present in the microbiome. Thus, herein we review recent studies demonstrating strong correlations between the microbiome of the oncology patient and infections occurring during chemotherapy. An increased knowledge of the interplay between potential pathogens, protective commensals, and the host immune system may facilitate the development of novel biomarkers or therapeutics that could help ameliorate the toll that infections take during the treatment of cancer.
中文翻译:
微生物群对癌症治疗期间细菌感染的影响
接受癌症治疗的患者发生感染性并发症的风险很高,这通常是由于定植生物通过破坏的上皮屏障进入无菌部位。人们逐渐认识到,包括耐多药生物在内的细菌病原体定植并随后感染人类的能力在很大程度上取决于微生物组中存在的保护性细菌种类。因此,在此我们回顾最近的研究,证明肿瘤患者的微生物组与化疗期间发生的感染之间存在很强的相关性。对潜在病原体、保护性共生体、