Obesity is now a worldwide health issue. Far from being limited to weight gain, obesity is generally associated with low-grade inflammation and with a cluster of disorders collectively known as the 'metabolic syndrome'. When considering obesity and the subsequent neuroinflammation, the focus was long set on the hypothalamus. More recently, obesity-derived neuroinflammation has been shown to affect other brain structures such as the hippocampus, cortex, brainstem, or amygdala. Furthermore, obesity has been associated with increased occurrence of central disorders such as depression and impaired cognitive function. We discuss here the effects and mechanisms of obesity-derived neuroinflammation, with a specific emphasis on extra-hypothalamic structures, as well as the repercussions of neuroinflammation for some cerebral functions.

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肥胖引起的神经炎症：超越下丘脑

肥胖现在是一个世界性的健康问题。肥胖不仅限于体重增加，而且通常与轻度炎症和一系列统称为“代谢综合征”的疾病有关。在考虑肥胖和随后的神经炎症时，重点一直放在下丘脑上。最近，肥胖衍生的神经炎症已被证明会影响其他大脑结构，如海马、皮层、脑干​​或杏仁核。此外，肥胖与中枢障碍的发生率增加有关，例如抑郁症和认知功能受损。我们在此讨论肥胖源性神经炎症的影响和机制，特别强调下丘脑外结构，以及神经炎症对某些脑功能的影响。