Age-related neurological disorders (ANDs), including neurodegenerative diseases, are multifactorial disorders with a risk that increases with aging. ANDs are generally characterized by common neuropathological conditions of the central nervous system, such as oxidative stress, neuroinflammation, and protein misfolding. Recently, efforts have been made to overcome ANDs because of the increase in age-dependent prevalence. Ginger, the rhizome of Zingiber officinale Roscoe, is a popular food spice and has a long history of use in traditional medicine for treating various disease symptoms. The structure-activity relationships of ginger phytochemicals show that ginger can be used to treat ANDs by targeting different ligand sites. This review shows that ginger and its constituents, such as 6-gingerol, 6-shogaol, 6-paradol, zingerone, and dehydrozingerone, are effective for ameliorating the neurological symptoms and pathological conditions of ANDs through by modulating cell death or cell survival signaling molecules. From this review, we conclude that the active ingredients in ginger have therapeutic potential in ANDs.

与年龄有关的神经系统疾病（AND），包括神经退行性疾病，是多因素疾病，其风险会随着年龄的增长而增加。AND通常以中枢神经系统的常见神经病理学疾病为特征，例如氧化应激，神经炎症和蛋白质错误折叠。近来，由于年龄依赖性患病率的增加，已经做出努力来克服AND。生姜，根茎生姜罗斯科（Roscoe）是一种受欢迎的食品香料，并且在传统医学中用于治疗各种疾病症状的历史悠久。姜植物化学物质的构效关系表明，姜可以通过靶向不同的配体位点来治疗AND。这项综述表明，生姜及其成分（例如6-姜油酚，6-shogaol，6-paradol，姜油酮和脱氢姜油酮）可通过调节细胞死亡或细胞存活信号分子来有效缓解ANDs的神经系统症状和病理状况。 。从这篇评论中，我们得出结论，生姜中的有效成分对ANDs具有治疗潜力。