Asthma is a complex inflammatory disease characterized by airway inflammation and hyperresponsiveness. The mechanisms associated with the development and progression of asthma have been widely studied in multiple populations and animal models, and these have revealed involvement of various cell types and activation of intracellular signaling pathways that result in activation of inflammatory genes. Significant contributions of Toll-like-receptors (TLRs) and transcription factors such as NF-кB, have been reported as major contributors to inflammatory pathways. These have also recently been associated with mechanisms of oxidative biology. This is of important clinical significance as the observed inefficacy of current available treatments for severe asthma is widely attributed to oxidative stress. Therefore, targeting oxidizing molecules in conjunction with inflammatory mediators and transcription factors may present a novel therapeutic strategy for asthma. In this review, we summarize TLRs and NF-кB pathways in the context of exacerbation of asthma pathogenesis and oxidative biology, and we discuss the potential use of polyphenolic flavonoid compounds, known to target these pathways and possess antioxidant activity, as potential therapeutic agents for asthma.

哮喘是一种复杂的炎症性疾病，其特征是气道炎症和高反应性。与哮喘发生和进展相关的机制已在多个人群和动物模型中进行了广泛研究，这些研究揭示了各种细胞类型的参与以及导致炎症基因激活的细胞内信号通路的激活。据报道，Toll 样受体 (TLR) 和转录因子（如 NF-кB）对炎症通路有重要贡献。这些最近也与氧化生物学机制相关。这具有重要的临床意义，因为目前观察到的严重哮喘治疗无效被广泛归因于氧化应激。因此，针对氧化分子与炎症介质和转录因子的结合可能为哮喘提供一种新的治疗策略。在这篇综述中，我们总结了哮喘发病机制恶化和氧化生物学背景下的 TLR 和 NF-кB 通路，并讨论了已知针对这些通路并具有抗氧化活性的多酚类黄酮化合物作为潜在治疗剂的潜在用途。哮喘。