Binge-eating disorder (BED) is the most prevalent eating disorder with estimates of 2–5% of the general adult population. Nonetheless, its pathophysiology is poorly understood. Furthermore, there exist few therapeutic options for its effective treatment. Here we review the current state of binge-eating neurobiology and pharmacology, drawing from clinical therapeutic, neuroimaging, cognitive, human genetic and animal model studies. These studies, which are still in their infancy, indicate that while there are many gaps in our knowledge, several key neural substrates appear to underpin binge-eating and may be conserved between human and animals. This observation suggests that behavioral intermediate phenotypes or endophenotypes relevant to BED may be modeled in animals, facilitating the identification and testing of novel pharmacological targets. The development of novel, safe and effective pharmacological therapies for the treatment of BED will enhance the ability of clinicians to provide optimal care for people with BED.

暴饮暴食症（BED）是最普遍的饮食失调症，估计占成年人口的2–5％。但是，对其病理生理学知之甚少。此外，几乎没有用于其有效治疗的治疗选择。在这里，我们从临床治疗，神经影像学，认知，人类遗传学和动物模型研究中回顾暴食神经生物学和药理学的现状。这些仍处于起步阶段的研究表明，尽管我们的知识尚有许多空白，但一些关键的神经底物似乎是暴饮暴食的基础，在人类和动物之间可能是保守的。该观察结果表明，可以在动物中模拟与BED相关的行为中间表型或内表型，从而有助于鉴定和测试新型药理学靶标。