In recent decades, there have been tremendous improvements in burn care that have allowed patients to survive severe burn injuries that were once fatal. However, a major limitation of burn care currently is the development of hypertrophic scars in approximately 70% of patients. This significantly decreases the quality of life for patients due to the physical and psychosocial symptoms associated with scarring. Current approaches to manage scarring include surgical techniques and non-surgical methods such as laser therapy, steroid injections, and compression therapy. These treatments are limited in their effectiveness and regularly fail to manage symptoms. As a result, the development of novel treatments that aim to improve outcomes and quality of life is imperative. Drug delivery that targets the molecular cascades of wound healing to attenuate or prevent hypertrophic scarring is a promising approach that has therapeutic potential. In this review, we discuss current treatments for scar management after burn injury, and how drug delivery targeting molecular signaling can lead to new therapeutic strategies.

近几十年来，烧伤护理取得了巨大进步，使患者能够从曾经致命的严重烧伤中幸存下来。然而，目前烧伤护理的一个主要限制是大约 70% 的患者会出现增生性疤痕。由于与疤痕相关的身体和心理社会症状，这显着降低了患者的生活质量。目前处理疤痕的方法包括手术技术和非手术方法，例如激光疗法、类固醇注射和压迫疗法。这些治疗方法的有效性有限，并且经常无法控制症状。因此，开发旨在改善结果和生活质量的新疗法势在必行。以伤口愈合的分子级联为目标的药物递送以减轻或预防增生性疤痕是一种具有治疗潜力的有前景的方法。在这篇综述中，我们讨论了烧伤后疤痕管理的当前治疗方法，以及靶向分子信号传导的药物输送如何导致新的治疗策略。