Recently failed antiamyloidogenic trials call for an objective reassessment of the dominating amyloid cascade hypothesis of Alzheimer’s disease (AD). Ongoing efforts focusing on amyloid β protein (Aβ), its deposition, and its removal need to be complemented by more intensive research in new directions. Those may either integrate amyloid pathology or will propose pathogenetic routes independent of Aβ in the search for the causes of AD.

中文翻译：

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阿尔茨海默氏病中的淀粉样蛋白：超出合理怀疑范围而有罪吗？

最近失败的抗淀粉样变性试验要求对阿尔茨海默氏病（AD）的主要淀粉样蛋白级联假说进行客观的重新评估。正在进行的针对淀粉样β蛋白（Aβ），其沉积和去除的工作需要在新方向上进行更深入的研究来补充。那些可能整合淀粉样蛋白病理学或将提出独立于Aβ的致病性途径以寻找AD的病因。