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Soft Matter in Lipid–Protein Interactions
Annual Review of Biophysics ( IF 10.4 ) Pub Date : 2017-05-22 00:00:00 , DOI: 10.1146/annurev-biophys-070816-033843
Michael F Brown 1, 2
Affiliation  

Membrane lipids and cellular water (soft matter) are becoming increasingly recognized as key determinants of protein structure and function. Their influences can be ascribed to modulation of the bilayer properties or to specific binding and allosteric regulation of protein activity. In this review, we first consider hydrophobic matching of the intramembranous proteolipid boundary to explain the conformational changes and oligomeric states of proteins within the bilayer. Alternatively, membranes can be viewed as complex fluids, whose properties are linked to key biological functions. Critical behavior and nonideal mixing of the lipids have been proposed to explain how raft-like microstructures involving cholesterol affect membrane protein activity. Furthermore, the persistence length for lipid–protein interactions suggests the curvature force field of the membrane comes into play. A flexible surface model describes how curvature and hydrophobic forces lead to the emergence of new protein functional states within the membrane lipid bilayer.

中文翻译:


脂质-蛋白质相互作用中的软物质

膜脂质和细胞水(软物质)越来越被认为是蛋白质结构和功能的关键决定因素。它们的影响可归因于双层特性的调节或蛋白质活性的特异性结合和变​​构调节。在这篇综述中,我们首先考虑膜内蛋白脂质边界的疏水匹配,以解释双层内蛋白质的构象变化和寡聚状态。或者,膜可以被视为复杂的流体,其特性与关键的生物功能相关。脂质的临界行为和非理想混合已被提出来解释涉及胆固醇的筏状微结构如何影响膜蛋白活性。此外,脂质-蛋白质相互作用的持续长度表明膜的曲率力场发挥作用。灵活的表面模型描述了曲率和疏水力如何导致膜脂双层内新的蛋白质功能状态的出现。

更新日期:2017-05-22
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