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Integration of Bacterial Small RNAs in Regulatory Networks
Annual Review of Biophysics ( IF 10.4 ) Pub Date : 2017-05-22 00:00:00 , DOI: 10.1146/annurev-biophys-070816-034058
Mor Nitzan 1, 2 , Rotem Rehani 1 , Hanah Margalit 1
Affiliation  

Small RNAs (sRNAs) are central regulators of gene expression in bacteria, controlling target genes posttranscriptionally by base pairing with their mRNAs. sRNAs are involved in many cellular processes and have unique regulatory characteristics. In this review, we discuss the properties of regulation by sRNAs and how it differs from and combines with transcriptional regulation. We describe the global characteristics of the sRNA–target networks in bacteria using graph-theoretic approaches and review the local integration of sRNAs in mixed regulatory circuits, including feed-forward loops and their combinations, feedback loops, and circuits made of an sRNA and another regulator, both derived from the same transcript. Finally, we discuss the competition effects in posttranscriptional regulatory networks that may arise over shared targets, shared regulators, and shared resources and how they may lead to signal propagation across the network.

中文翻译:


细菌小RNA在监管网络中的整合。

小RNA(sRNA)是细菌中基因表达的中心调节剂,通过与mRNA的碱基配对在转录后控制靶基因。sRNA参与许多细胞过程,并具有独特的调节特性。在这篇综述中,我们讨论了sRNA调控的特性以及它与转录调控的区别和组合。我们使用图论方法描述细菌中sRNA靶标网络的全局特征,并回顾了sRNA在混合调节回路中的局部整合,包括前馈回路及其组合,反馈回路以及由sRNA和其他分子组成的回路调节子,两者均来自同一笔录。最后,我们讨论了转录后监管网络中可能因共同目标而产生的竞争效应,

更新日期:2017-05-22
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