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Trefoil Factor Peptides and Gastrointestinal Function
Annual Review of Physiology ( IF 15.7 ) Pub Date : 2017-02-13 00:00:00 , DOI: 10.1146/annurev-physiol-021115-105447
Eitaro Aihara 1 , Kristen A. Engevik 1 , Marshall H. Montrose 1
Affiliation  

Trefoil factor (TFF) peptides, with a 40-amino acid motif and including six conserved cysteine residues that form intramolecular disulfide bonds, are a family of mucin-associated secretory molecules mediating many physiological roles that maintain and restore gastrointestinal (GI) mucosal homeostasis. TFF peptides play important roles in response to GI mucosal injury and inflammation. In response to acute GI mucosal injury, TFF peptides accelerate cell migration to seal the damaged area from luminal contents, whereas chronic inflammation leads to increased TFF expression to prevent further progression of disease. Although much evidence supports the physiological significance of TFF peptides in mucosal defenses, the molecular and cellular mechanisms of TFF peptides in the GI epithelium remain largely unknown. In this review, we summarize the functional roles of TFF1, 2, and 3 and illustrate their action mechanisms, focusing on defense mechanisms in the GI tract.

中文翻译:


三叶因子肽和胃肠功能

三叶因子(TFF)肽具有40个氨基酸的基序,并且包括形成分子内二硫键的六个保守的半胱氨酸残基,是黏蛋白相关分泌分子家族,介导维持和恢复胃肠道(GI)粘膜稳态的许多生理作用。TFF肽在对胃肠道粘膜损伤和炎症反应中起重要作用。在对急性胃肠道粘膜损伤作出反应时,TFF肽加速细胞迁移以从腔内容物中密封受损区域,而慢性炎症导致TFF表达增加以防止疾病进一步发展。尽管有大量证据支持TFF肽在粘膜防御中的生理学意义,但GI上皮中TFF肽的分子和细胞机制仍然未知。在这篇评论中,

更新日期:2017-02-13
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