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The Central Control of Energy Expenditure: Exploiting Torpor for Medical Applications
Annual Review of Physiology ( IF 15.7 ) Pub Date : 2017-02-13 00:00:00 , DOI: 10.1146/annurev-physiol-022516-034133
Matteo Cerri 1
Affiliation  

Autonomic thermoregulation is a recently acquired function, as it appears for the first time in mammals and provides the brain with the ability to control energy expenditure. The importance of such control can easily be highlighted by the ability of a heterogeneous group of mammals to actively reduce metabolic rate and enter a condition of regulated hypometabolism known as torpor. The central neural circuits of thermoregulatory cold defense have been recently unraveled and could in theory be exploited to reduce energy expenditure in species that do not normally use torpor, inducing a state called synthetic torpor. This approach may represent the first steps toward the development of a technology to induce a safe and reversible state of hypometabolism in humans, unlocking many applications ranging from new medical procedures to deep space travel.

中文翻译:


能源支出的中央控制:为医疗应用开发Torpor

自主温度调节是最近获得的功能,因为它在哺乳动物中首次出现,并为大脑提供控制能量消耗的能力。这种控制的重要性可以很容易地通过异质类哺乳动物主动降低代谢速率并进入被称为torpor的调节性低代谢状态的能力来突出。温度调节冷防御的中央神经回路最近已被揭开,并且在理论上可以被用来减少通常不使用to的物种的能量消耗,从而产生一种称为合成to的状态。这种方法可能代表了一种技术的发展的第一步,该技术可诱导人体内代谢的安全性和可逆性,从而解锁了从新医疗程序到深空旅行的许多应用。

更新日期:2017-02-13
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