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Irritability in Children and Adolescents*
Annual Review of Clinical Psychology ( IF 17.8 ) Pub Date : 2017-05-08 00:00:00 , DOI: 10.1146/annurev-clinpsy-032816-044941
Melissa A. Brotman 1 , Katharina Kircanski 1 , Ellen Leibenluft 1
Affiliation  

Irritability is a common and impairing clinical presentation in children and adolescents. Despite its significant public health impact, irritability remains an elusive construct. Chronic and severe irritability is the primary symptom of the new DSM-5 diagnosis, disruptive mood dysregulation disorder (DMDD). However, empirical and clinical approaches to irritability are in their relative infancy, and questions regarding the validity of the DMDD diagnosis have been raised. Moreover, irritability is a trait distributed continuously in youth, thereby fitting within the National Institute of Mental Health Research Domain Criteria initiative. Thus, there are opportunities for scientific review and integration. Accordingly, the goals of this review include (a) clarifying the definitions of irritability, incorporating clinical and translational animal work; (b) reviewing the historical context surrounding the study of irritability; (c) reviewing the prevalence, clinical correlates, and longitudinal course of irritability; (d) presenting behavioral and neurobiological findings associated with irritability; and (e) exploring treatment options and proposing future directions for research.

中文翻译:


儿童和青少年的烦躁*

易怒性是儿童和青少年常见且损害临床表现的因素。尽管它对公共卫生有重大影响,但烦躁情绪仍然难以捉摸。慢性和严重易怒是新的DSM-5诊断的主要症状,即破坏性情绪失调障碍(DMDD)。但是,有关易怒性的经验和临床方法尚处于初期阶段,并且已经提出了有关DMDD诊断有效性的问题。此外,易怒是在青年中持续分布的特征,因此符合美国国家心理健康研究所的领域标准倡议。因此,存在进行科学审查和整合的机会。因此,本次审查的目标包括()结合临床和翻译动物工作,阐明易怒的定义;(b)回顾有关易怒性研究的历史背景;(c)回顾患病率,临床相关性和易怒性的纵向过程;(d)提出与易怒有关的行为和神经生物学发现;(e)探索治疗方案,并提出未来的研究方向。

更新日期:2017-05-08
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