Rationale: Up to one-third of patients hospitalized with pneumococcal pneumonia experience major adverse cardiac events (MACE) during or after pneumonia. In mice, Streptococcus pneumoniae can invade the myocardium, induce cardiomyocyte death, and disrupt cardiac function following bacteremia, but it is unknown whether the same occurs in humans with severe pneumonia.

中文翻译：

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严重的肺炎球菌性肺炎导致急性心脏毒性和随后的心脏重塑

理由：肺炎球菌性肺炎住院的患者中，多达三分之一在肺炎期间或之后经历严重的不良心脏事件（MACE）。在小鼠中，肺炎链球菌可侵袭心肌，诱发心肌细胞死亡，并在菌血症后破坏心脏功能，但尚不清楚在重度肺炎的人类中是否也会发生这种情况。