DNA damage elicits a potent proinflammatory immune response. A collection of four papers now reveals that micronuclear DNA is a new cell intrinsic immunostimulatory molecule, and that accumulation of the immune sensor cyclic GMP–AMP synthase (cGAS) in micronuclei leads to a cell-cycle-dependent proinflammatory response following DNA damage.

中文翻译：

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cGAS进行微核DNA监测

DNA损伤引起有效的促炎性免疫反应。现在，四篇论文的集合揭示了微核DNA是一种新的细胞内在免疫刺激分子，而免疫传感器环状GMP-AMP合酶（cGAS）在微核中的积累会导致DNA损伤后依赖细胞周期的促炎反应。