Alterations in cellular aging, indexed by leukocyte telomere length (LTL) and mitochondrial DNA copy number (mtDNAcn), might partly account for the increased health risks in persons with depression. Although some studies indeed found cross-sectional associations of depression with LTL and mtDNAcn, the longitudinal associations remain unclear. This 10-year longitudinal study examined between- and within-person associations of depressive symptoms with LTL and mtDNAcn in a large community sample. Data are from years 15, 20 and 25 follow-up evaluations in 977 subjects from the Coronary Artery Risk Development in Young Adults study. Depressive symptoms (years 15, 20, 25) were assessed with the Center for Epidemiologic Studies Depression (CES-D) scale; LTL (years 15, 20, 25) and mtDNAcn (years 15, 25) were measured in whole blood by quantitative PCR. With mixed-model analyses, we explored between- and within-person associations between CES-D scores and cellular aging markers. Results showed that high levels of depressive symptomatology throughout the 10-year time span was associated with shorter average LTL over 10 years (B=-4.2; P=0.014) after covarying for age, sex, race and education. However, no within-person association was found between depressive symptoms and LTL at each year (B=-0.8; P=0.548). Further, we found no between-person (B=-0.2; P=0.744) or within-person (B=0.4; P=0.497) associations between depressive symptomatology and mtDNAcn. Our results provide evidence for a long-term, between-person relationship of depressive symptoms with LTL, rather than a dynamic and direct within-person relationship. In this study, we found no evidence for an association between depressive symptoms and mtDNAcn.

中文翻译：

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抑郁症，端粒和线粒体DNA：来自一项为期十年的纵向研究的人际关系和人际关系。

以白细胞端粒长度（LTL）和线粒体DNA拷贝数（mtDNAcn）为指标的细胞衰老变化可能部分解释了抑郁症患者健康风险的增加。尽管确实有一些研究发现抑郁症与LTL和mtDNAcn的横断面关联，但纵向关联仍不清楚。这项为期十年的纵向研究在一个大型社区样本中研究了抑郁症状与LTL和mtDNAcn的人际关系和人际关系。数据来自年轻成年人冠状动脉风险发展研究中的977位受试者的15、20和25年随访评估。抑郁症状（15、20、25年）通过流行病学研究中心抑郁症（CES-D）量表进行评估；通过定量PCR测定全血中的LTL（第15、20、25年）和mtDNAcn（第15、25年）。通过混合模型分析，我们探索了CES-D得分与细胞衰老标记之间的人际关系和人际关系。结果表明，在对年龄，性别，种族和文化程度进行变通之后，在整个10年的时间里，抑郁症状的高水平与10年内平均LTL较短（B = -4.2； P = 0.014）有关。但是，每年在抑郁症状和LTL之间均未发现人与人之间的关联（B = -0.8； P = 0.548）。此外，我们发现抑郁症状与mtDNAcn之间没有人际关系（B = -0.2； P = 0.744）或人际关系（B = 0.4； P = 0.497）。我们的结果为抑郁症状与LTL的长期人际关系提供了证据，而不是动态而直接的人际关系提供了证据。在这项研究中，