Preventing tumor recurrence after surgical resection of a brain tumor is a significant clinical challenge because current methods deliver chemotherapeutic agents in a rapid manner and are not effective against the residual tumor cells. To overcome this drawback, we report a simple method to prepare magnetic resonance imaging (MRI) traceable ultra-thermosensitive hydrogels with rapid gelation ability from aqueous solution within 4 s at 28 °C for hydrophilic (epirubicin, EPI) and hydrophobic (paclitaxel, PTX) drugs co-delivery with bovine serum albumin nanoparticles (BSA NPs) incorporation. The results showed the average survival of gliosarcoma-bearing (MBR 614 or U87) mice receiving BSA/PTX NPs incorporated hydrogel_Gd/EPI increased to 63 days or 69 days with no tumor recurrence observed. Our synergistic strategy presents a new approach to the development of a local drug delivery system for the prevention of brain tumor recurrence.

中文翻译：

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快速原位MRI可追踪的凝胶形成双药递送，用于脑肿瘤的协同治疗。

预防脑肿瘤手术切除后的肿瘤复发是一项重大的临床挑战，因为当前的方法以快速的方式递送化学治疗剂并且对残留的肿瘤细胞无效。为了克服这个缺点，我们报告了一种简单的方法来制备磁共振成像（MRI）可追踪的超热敏水凝胶，该凝胶在28°C的4 s内可从水溶液中快速凝胶化，用于亲水性（埃比霉素，EPI）和疏水性（紫杉醇，PTX ）与牛血清白蛋白纳米颗粒（BSA NPs）掺入共同递送。结果显示，接受掺入水凝胶_Gd的BSA / PTX NPs的滑膜肉瘤（MBR 614或U87）小鼠的平均存活时间/ EPI增加至63天或69天，未观察到肿瘤复发。我们的协同策略为开发预防脑肿瘤复发的局部药物输送系统提供了一种新方法。