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Acylglycerol Kinase: Mitochondrial Protein Transport Meets Lipid Biosynthesis
Trends in Cell Biology ( IF 13.0 ) Pub Date : 2017-08-31 , DOI: 10.1016/j.tcb.2017.08.006 Christoph U. Mårtensson , Thomas Becker
中文翻译:
酰基甘油激酶:线粒体蛋白运输遇到脂质生物合成。
更新日期:2017-08-31
Trends in Cell Biology ( IF 13.0 ) Pub Date : 2017-08-31 , DOI: 10.1016/j.tcb.2017.08.006 Christoph U. Mårtensson , Thomas Becker
The carrier translocase (TIM22 complex) inserts hydrophobic proteins into the mitochondrial inner membrane. Recently, the acylglycerol kinase (AGK) mutated in Sengers syndrome was identified as a novel subunit of the human TIM22 complex. This finding reveals an exciting link between mitochondrial protein and lipid biogenesis.
中文翻译:
酰基甘油激酶:线粒体蛋白运输遇到脂质生物合成。
载体转位酶(TIM22复合物)将疏水蛋白插入线粒体内膜。最近,在Sengers综合征中突变的酰基甘油激酶(AGK)被鉴定为人类TIM22复合体的一个新的亚基。这一发现揭示了线粒体蛋白与脂质生物发生之间令人兴奋的联系。