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NAFLD: PNPLA3 and obesity: a synergistic relationship in NAFLD
Nature Reviews Gastroenterology & Hepatology ( IF 45.9 ) Pub Date : 2017-06-14 , DOI: 10.1038/nrgastro.2017.74 Jake P. Mann , Quentin M. Anstee
Nature Reviews Gastroenterology & Hepatology ( IF 45.9 ) Pub Date : 2017-06-14 , DOI: 10.1038/nrgastro.2017.74 Jake P. Mann , Quentin M. Anstee
NAFLD, the hepatic manifestation of the metabolic syndrome, is a multifactorial condition — environmental factors influence an inherited genetic risk. Stender et al. now describe the additive effect of obesity and NAFLD-associated genetic polymorphisms on steatosis, elevated serum alanine aminotransferase levels and cirrhosis, remarkably illustrating the principle of gene–environment interactions.
中文翻译:
NAFLD:PNPLA3与肥胖:NAFLD中的协同关系
NAFLD是代谢综合征的肝脏表现,是一种多因素疾病-环境因素会影响遗传的遗传风险。Stender等。现在描述肥胖和与NAFLD相关的遗传多态性对脂肪变性,血清丙氨酸氨基转移酶水平升高和肝硬化的累加作用,从而显着说明了基因与环境相互作用的原理。
更新日期:2017-08-31
中文翻译:
NAFLD:PNPLA3与肥胖:NAFLD中的协同关系
NAFLD是代谢综合征的肝脏表现,是一种多因素疾病-环境因素会影响遗传的遗传风险。Stender等。现在描述肥胖和与NAFLD相关的遗传多态性对脂肪变性,血清丙氨酸氨基转移酶水平升高和肝硬化的累加作用,从而显着说明了基因与环境相互作用的原理。