ERG overexpression in prostate cancers promotes the development of widespread changes in gene expression and chromatin landscapes, leading to redistribution of key transcription factors in prostate cancers positive for the TMPRSS2-ERG fusion gene. The overexpression of ERG is further assisted by the development of a super-enhancer in the ERG locus.

中文翻译：

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扩大ERG对染色质景观和前列腺癌转录失调的影响。

前列腺癌中的ERG过表达促进了基因表达和染色质分布的广泛变化，从而导致关键转录因子在TMPRSS2-ERG融合基因阳性的前列腺癌中重新分布。ERG基因座中超级增强子的发展进一步帮助了ERG的过表达。