Due to the complexity of biological systems and samples, specific capture and targeting of certain biomolecules is critical in much biological research and many applications. cis-Diol-containing biomolecules, a large family of important compounds including glycoproteins, saccharides, nucleosides, nucleotides, and so on, play essential roles in biological systems. As boronic acids can reversibly bind with cis-diols, boronate affinity materials (BAMs) have gained increasing attention in recent years. However, real-world applications of BAMs are often severely hampered by three bottleneck issues, including nonbiocompatible binding pH, weak affinity, and difficulty in selectivity manipulation. Therefore, solutions to these issues and knowledge about the factors that influence the binding properties are of significant importance.

中文翻译：

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硼酸酯亲和材料的合成与应用：从类别选择性到仿生特异性

由于生物系统和样品的复杂性，某些生物分子的特异性捕获和靶向在许多生物学研究和许多应用中至关重要。含顺式二醇的生物分子是一大类重要的化合物，包括糖蛋白，糖类，核苷，核苷酸等，在生物系统中起着至关重要的作用。由于硼酸可以与顺式结合-二醇，硼酸酯亲和材料（BAM）近年来受到越来越多的关注。但是，BAM在现实世界中的应用通常受到三个瓶颈问题的严重阻碍，其中包括非生物相容性结合pH，弱亲和力和选择性操纵的困难。因此，对于这些问题的解决方案以及有关影响结合特性的因素的知识非常重要。