At the centenary of D'Arcy Thompson's seminal work 'On Growth and Form', pioneering the description of principles of morphological changes during development and evolution, recent experimental advances allow us to study change in anatomical brain networks. Here, we outline potential principles for connectome development. We will describe recent results on how spatial and temporal factors shape connectome development in health and disease. Understanding the developmental origins of brain diseases in individuals will be crucial for deciding on personalized treatment options. We argue that longitudinal studies, experimentally derived parameters for connection formation, and biologically realistic computational models are needed to better understand the link between brain network development, network structure, and network function.

中文翻译：

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连接体发育机制

在达西·汤普森 (D'Arcy Thompson) 开创性著作《论生长与形态》(On Growth and Form) 一百周年之际，开创了描述发育和进化过程中形态变化原理的先河，最近的实验进展使我们能够研究解剖大脑网络的变化。在这里，我们概述了连接组发展的潜在原则。我们将描述关于空间和时间因素如何影响健康和疾病中的连接组发育的最新结果。了解个体脑部疾病的发育起源对于决定个性化治疗方案至关重要。我们认为，为了更好地理解大脑网络发展、网络结构和网络功能之间的联系，需要纵向研究、实验得出的连接形成参数和生物学上真实的计算模型。