Annual Review of Cell and Developmental Biology ( IF 11.4 ) Pub Date : 2016-10-06 00:00:00 , DOI: 10.1146/annurev-cellbio-111315-124944 Noelia Escobedo 1 , Guillermo Oliver 2
The two vascular systems of our body are the blood and the lymphatic vasculature. Our understanding of the genes and molecular mechanisms controlling the development of the lymphatic vasculature network has significantly improved. The availability of novel animal models and better imaging tools led to the identification of lymphatics in tissues and organs previously thought to be devoid of them. Similarly, the classical textbook list of established functional roles of the lymphatic system has been expanded by the addition of novel findings. In this review we provide a historical perspective of some of the important landmarks that opened the doors to researchers working in this field. We also summarize some of the current views about embryonic lymphangiogenesis, particularly about the source(s), commitment, and differentiation of lymphatic endothelial cells.
中文翻译:
淋巴管生成:起源,规范和细胞命运的确定。
我们身体的两个血管系统是血液和淋巴管。我们对控制淋巴管网络发展的基因和分子机制的了解已大大改善。新颖的动物模型和更好的成像工具的出现导致人们对以前认为没有它们的组织和器官中的淋巴管进行了鉴定。同样,通过增加新发现扩大了经典教科书中已确立的淋巴系统功能作用的清单。在这篇评论中,我们提供了一些重要地标的历史视角,为该领域的研究人员打开了大门。我们还将总结一些有关胚胎淋巴管生成的最新观点,尤其是有关来源,承诺,