当前位置: X-MOL 学术Annu. Rev. Cell Dev. Biol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Phosphoinositides in Control of Membrane Dynamics
Annual Review of Cell and Developmental Biology ( IF 11.4 ) Pub Date : 2016-10-06 00:00:00 , DOI: 10.1146/annurev-cellbio-111315-125349
Kay O. Schink 1, 2 , Kia-Wee Tan 1, 2 , Harald Stenmark 1, 2, 3
Affiliation  

Most functions of eukaryotic cells are controlled by cellular membranes, which are not static entities but undergo frequent budding, fission, fusion, and sculpting reactions collectively referred to as membrane dynamics. Consequently, regulation of membrane dynamics is crucial for cellular functions. A key mechanism in such regulation is the reversible recruitment of cytosolic proteins or protein complexes to specific membranes at specific time points. To a large extent this recruitment is orchestrated by phosphorylated derivatives of the membrane lipid phosphatidylinositol, known as phosphoinositides. The seven phosphoinositides found in nature localize to distinct membrane domains and recruit distinct effectors, thereby contributing strongly to the maintenance of membrane identity. Many of the phosphoinositide effectors are proteins that control membrane dynamics, and in this review we discuss the functions of phosphoinositides in membrane dynamics during exocytosis, endocytosis, autophagy, cell division, cell migration, and epithelial cell polarity, with emphasis on protein effectors that are recruited by specific phosphoinositides during these processes.

中文翻译:


磷脂酰肌醇在膜动力学控制中的作用

真核细胞的大多数功能由细胞膜控制,细胞膜不是静态实体,而是会经历频繁的出芽,裂变,融合和雕刻反应,统称为膜动力学。因此,调节膜动力学对于细胞功能至关重要。这种调节的关键机制是在特定的时间点将胞浆蛋白或蛋白复合物可逆地募集到特定的膜上。在很大程度上,这种募集是通过膜脂质磷脂酰肌醇的磷酸化衍生物(称为磷酸肌醇)来协调的。在自然界中发现的七个磷酸肌醇定位于不同的膜结构域并募集不同的效应子,从而对维持膜同一性做出了重要贡献。

更新日期:2016-10-06
down
wechat
bug