SMADs are essential transcriptional effectors of transforming growth factor-β (TGFβ)/TGFβ-related signaling that underlies embryonic development and adult homeostasis. A recent study by Fang et al. in Cell Research adds to this biological complexity by demonstrating an atypical cytoplasmic role for SMAD5 in modulating the bioenergetic homeostasis (i.e., glycolysis and mitochondrial respiration) of cells in response to fluctuations in intracellular pH that is independent of receptor signaling.

中文翻译：

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SMAD5信号转导：不仅仅与细胞核相遇。

SMAD是转化生长因子-β（TGFβ）/TGFβ相关信号的重要转录效应子，是胚胎发育和成人体内稳态的基础。方等人的最新研究。在Cell Research中，通过证明SMAD5在响应细胞内pH波动（独立于受体信号传导）而调节细胞的生物能稳态（即糖酵解和线粒体呼吸）中具有非典型的细胞质作用，从而增加了这种生物学上的复杂性。