Chemoselective Continuous Ru-Catalyzed Hydrogen-Transfer Oppenauer-Type Oxidation of Secondary Alcohols,Organic Process Research & Development

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Chemoselective Continuous Ru-Catalyzed Hydrogen-Transfer Oppenauer-Type Oxidation of Secondary Alcohols
Organic Process Research & Development ( IF 3.1 ) Pub Date : 2017-08-18 00:00:00 , DOI: 10.1021/acs.oprd.7b00190
Ricardo Labes ₁ , Claudio Battilocchio ₁ , Carlos Mateos ₂ , Graham R. Cumming ₂ , Oscar de Frutos ₂ , Juan A. Rincón ₂ , Kellie Binder ₃ , Steven V. Ley ₁

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A continuous flow method for the selective oxidation of secondary alcohols is reported. The method is based on an Oppenauer-type ruthenium-catalyzed hydrogen-transfer process that uses acetone as both solvent and oxidant. The process utilizes a low loading (1 mol%) of the commercially available ruthenium catalyst [Ru(p-cymene)Cl₂]₂ and triethylamine as a base and can be successfully applied to a range of different substrates, with a good level of functional group tolerance.

中文翻译：

仲醇的化学选择性连续Ru催化氢转移Oppenauer型氧化。

报道了用于选择性氧化仲醇的连续流方法。该方法基于Oppenauer型钌催化的氢转移过程，该过程使用丙酮作为溶剂和氧化剂。该方法利用低负载量（1 mol％）的市售钌催化剂[Ru（p- Cymene）Cl ₂ ] ₂和三乙胺作为碱，可以成功地应用于各种不同的底物上，并具有良好的功能组耐受性。

更新日期：2017-08-18

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