Bis(trichloromethyl)carbonate (BTC, triphosgene) is a versatile compound that enables highly efficient syntheses. In addition, because of its solid state, it is a very convenient compound for small-scale phosgenations. Consequently, this compound is favored as a phosgene substitute in research and development and in small-scale production. Although BTC is highly toxic, safe handling is possible as long as the properties and chemical reactivity of this compound are understood and considered. However, branding as “safe phosgene” or “safer phosgene” is misleading. The solid state of BTC leads to the misconception that there is no significant exposure. However, the vapor pressure is sufficiently high to easily result in toxic concentrations. In addition, proper monitoring is not yet possible. Proper use of BTC could be more complex than the handling of phosgene itself. However, handling of BTC is normally always associated with phosgene and has its own toxicity. Therefore, the use of BTC will become more regulated in the future, which will directly increase responsibility in route selection during process development. A stringent safety concept for phosgenations using BTC is necessary. Because of the interconnection with phosgene, the safety concept for BTC will likely be an extended version of the safety concept for phosgene.

中文翻译：

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碳酸二（三氯甲基）酯（BTC，三光气）：光气的更安全替代品？

碳酸二（三氯甲基）酯（BTC，三光气）是一种通用化合物，可实现高效合成。另外，由于其固态，它是用于小规模光气化的非常方便的化合物。因此，该化合物在研究和开发以及小规模生产中均被用作光气替代品。尽管BTC有剧毒，但只要了解并考虑到该化合物的性质和化学反应性，便可以安全处理。但是，将品牌称为“安全光气”或“更安全的光气”具有误导性。BTC的固态状态导致误解，认为没有明显的暴露。然而，蒸气压足够高以容易导致毒性浓度。此外，尚无法进行适当的监视。正确使用BTC可能比处理光气本身更复杂。但是，BTC的处理通常总是与光气有关，并具有其自身的毒性。因此，将来BTC的使用将变得更加规范，这将直接增加工艺开发过程中路线选择的责任。使用BTC进行光气化有严格的安全概念是必要的。由于与光气的互连，BTC的安全性概念很可能是光气安全性概念的扩展版本。使用BTC进行光气化有严格的安全概念是必要的。由于与光气的互连，BTC的安全性概念很可能是光气安全性概念的扩展版本。使用BTC进行光气化有严格的安全概念是必要的。由于与光气的互连，BTC的安全性概念很可能是光气安全性概念的扩展版本。