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Signaling and Immune Regulation in Melanoma Development and Responses to Therapy
Annual Review of Pathology: Mechanisms of Disease ( IF 28.4 ) Pub Date : 2017-01-30 00:00:00 , DOI: 10.1146/annurev-pathol-052016-100208
William M. Lin 1 , David E. Fisher 1, 2
Affiliation  

Melanoma is a complex and genomically diverse malignancy, and new genes and signaling pathways involved in pathogenesis continue to be discovered. Mechanistic insights into gene and immune regulation in melanoma have led to the development of numerous successful and innovative pharmacologic agents over recent years. Multiple targeted therapies and immunotherapies have already entered the clinic, becoming new standards of care and transforming the prognosis for many patients with malignant melanoma. In this review, we provide an overview of the current understanding of signaling and immune regulation in melanoma and implications for responses to treatment, organized in the framework of hallmark characteristics in cancer.

中文翻译:


黑色素瘤发展和对治疗的反应中的信号传导和免疫调节

黑色素瘤是一种复杂的基因组多样的恶性肿瘤,与发病机理有关的新基因和信号通路不断被发现。近年来,对黑素瘤中基因和免疫调节的机理研究导致了许多成功和创新的药理学药物的发展。多种靶向疗法和免疫疗法已经进入临床,成为新的护理标准,并改变了许多恶性黑色素瘤患者的预后。在这篇综述中,我们提供了对黑素瘤信号传导和免疫调节的当前理解以及对治疗反应的暗示的概述,这些认识是在癌症的标志性特征框架内组织的。

更新日期:2017-01-30
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