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The Microscope as a Tool for Disease Discovery-A Personal Voyage.
Annual Review of Pathology: Mechanisms of Disease ( IF 28.4 ) Pub Date : 2017-01-30 00:00:00 , DOI: 10.1146/annurev-pathol-052016-100351
Elaine S Jaffe 1
Affiliation  

This review reflects the trajectory of my career in hematopathology, and my personal reflections on scientific advances in the field. During the course of more than 40 years, the approach to classification of hematological malignancies has evolved from descriptive approaches, based on either cytological or clinical features, to a modern approach, which incorporates cutting-edge technologies. My philosophy has focused on defining individual diseases, an approach that can best lead to an understanding of molecular pathogenesis. To quote Carolus Linnaeus (1, p. 19), the father of taxonomy, “The first step in wisdom is to know the things themselves; this notion consists in having a true idea of the objects; objects are distinguished and known by classifying them methodically and giving them appropriate names. Therefore, classification and name-giving will be the foundation of our science.

中文翻译:


显微镜作为疾病发现的工具-个人航行。

这篇评论反映了我在血液病理学领域的发展轨迹,以及我对这一领域科学进步的个人看法。在过去的40多年中,血液恶性肿瘤的分类方法已经从基于细胞学或临床特征的描述性方法演变为结合了尖端技术的现代方法。我的哲学专注于定义个体疾病,这种方法可以最好地导致人们对分子发病机理的理解。用分类学之父卡洛斯·林奈(1,p。19)的话来说:“智慧的第一步是了解事物本身;这个概念在于对对象有一个真实的想法。通过系统地对对象进行分类并为其指定适当的名称,可以区分和知道对象。所以,

更新日期:2017-01-30
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