Studies of aryl phosphonate derivatives of a butyrophilin 3A1 ligand have resulted in identification of a potent stimulant of Vγ9 Vδ2 T cells. This compound, a mixed ester bearing one pivaloyloxymethyl substituent and one 1-naphthyl ester displayed an EC₅₀ of 0.79 nM as a stimulant of T cell proliferation, and a 9.0 nM EC₅₀ in an assay designed to measure interferon gamma production. In both assays, this is the most potent butyrophilin ligand prodrug yet reported, and thus it should be a valuable tool for studies of T cell function. Furthermore, mixed aryl/acyloxyalkyl esters may represent a new class of phosphonate prodrugs with high efficacy.

中文翻译：

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Butyrophilin配体的混合芳基膦酸酯前药

对butyrophilin 3A1配体的芳基膦酸酯衍生物的研究已导致鉴定出有效的Vγ9Vδ2T细胞刺激物。该化合物是带有一个新戊酰氧基甲基取代基和一个1-萘基酯的混合酯，在刺激T细胞增殖的试验中，EC ₅₀为0.79 nM，刺激T细胞增殖为9.0 nM EC ₅₀。在这两种测定中，这都是迄今报道的最有效的嗜酪蛋白配体前体药物，因此，它应该是研究T细胞功能的有价值的工具。此外，混合的芳基/酰氧基烷基酯可以代表具有高功效的一类新的膦酸酯前药。