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Tumour-bound RNA-laden exosomes
Nature Biomedical Engineering ( IF 26.8 ) Pub Date : 2017-08-09 , DOI: 10.1038/s41551-017-0119-4 Sander A. A. Kooijmans , Pieter Vader , Raymond M. Schiffelers
Nature Biomedical Engineering ( IF 26.8 ) Pub Date : 2017-08-09 , DOI: 10.1038/s41551-017-0119-4 Sander A. A. Kooijmans , Pieter Vader , Raymond M. Schiffelers
Tumour-bound RNA-laden exosomes
中文翻译:
肿瘤结合RNA的外泌体
肿瘤结合RNA的外泌体
更新日期:2017-08-09
Nature Biomedical Engineering, Published online: 9 August 2017; doi:10.1038/s41551-017-0119-4
Exosomes expressing CD47 and loaded with interfering RNA dodge phagocytosis and accumulate in pancreatic tumours to silence the expression of the oncogene Kras in mice, with remarkable therapeutic efficacy.
中文翻译:
肿瘤结合RNA的外泌体
肿瘤结合RNA的外泌体
《自然生物医学工程》,在线发布:2017年8月9日;doi:10.1038 / s41551-017-0119-4
表达CD47并带有干扰RNA的外泌体可躲避吞噬作用并在胰腺肿瘤中蓄积,从而使癌基因Kras在小鼠中的表达沉默,具有显着的治疗功效。