Increasing bacterial resistance against current antibiotics and lack of new molecules to combat bacterial resistance are key challenges to global health. There is, therefore, a continuing need to develop new antibiotics. Teixobactin, a cyclic undecapeptide, displays excellent antibacterial activities against a range of pathogenic bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA) and Mycobacterium tuberculosis. Interestingly, it operates by multiple modes of actions and is bactericidal toward S. aureus without detectable resistance. This unique combination of wide Gram-positive activity coupled with its inability to elicit resistance make teixobactin a very attractive molecule for antimicrobial therapeutic development. This Viewpoint discusses teixobactin, its analogues, and the challenges and opportunities associated with their future development.

中文翻译：

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Teixobactin及其类似物：抗生素发现的新希望

对当前抗生素的细菌抵抗力的增强和缺乏抵抗细菌抵抗力的新分子是全球健康的关键挑战。因此，持续需要开发新的抗生素。Teixobactin是一种环状十一肽，对多种致病细菌（例如耐甲氧西林的金黄色葡萄球菌（MRSA）和结核分枝杆菌）表现出出色的抗菌活性。有趣的是，它通过多种作用方式起作用，并且对金黄色葡萄球菌具有杀菌作用。没有可检测的抵抗力。广泛的革兰氏阳性活性的独特结合及其无法引起耐药性，使得替考贝辛成为抗微生物治疗开发中非常有吸引力的分子。该观点讨论了teixobactin及其类似物，以及与其未来发展相关的挑战和机遇。