Owing to their hypotoxicity, great spatial resolution and tomographic properties, Fe₃O₄ nanoparticles (NPs) are becoming one of the most promising materials for noninvasive biological imaging and shape-dependent therapeutic agents for malignant tumor therapy. Conventional spherical NPs are unable to effectively destroy cellular structure in therapy and thus result in tumors with a high risk of drug resistance. Herein we developed a novel flower-like targeting Fe₃O₄@Au-HPG-Glc nanoprobe (thiol-containing hyperbranched polyglycerol (HPG); 4-aminophenyl β-D-glucopyranoside (Glc)) that can enhance magnetic resonance imaging (MRI) for cancer therapy. With the guidance of a targeting molecule, Fe₃O₄@Au-HPG-Glc nanoprobes can precisely target tumor cells. Under an alternating magnetic field (AMF), the flower-like Fe₃O₄@Au-HPG-Glc nanoprobes can rotate along the central axis of the core to substantially destroy tumor cells by damaging the nucleus or cell membrane. Our results showed that this shape-dependent therapeutic agent-based strategy had remarkable efficacy for MRI-guided tumor therapy. Furthermore, the inhibition of tumor growth in tumor-bearing mice was up to approximately 47.3% on the twelfth day of treatment compared with the level of inhibition in a blank group. Different from other reported methods for cancer therapy, our proposed AMF-dependent targeted cancer therapy is a novel strategy that can potentially reduce drug resistance in gastric tumors.

由于其低毒性，高空间分辨率和断层扫描特性，Fe ₃ O ₄纳米颗粒（NPs）成为用于无创生物成像和恶性肿瘤治疗的形状依赖型治疗剂的最有希望的材料之一。常规的球形NP在治疗中不能有效破坏细胞结构，因此导致具有高耐药性风险的肿瘤。在这里，我们开发了一种新型的花状靶向Fe ₃ O ₄ @ Au-HPG-Glc纳米探针（含硫醇的超支化聚甘油（HPG）； 4-氨基苯基β- D-吡喃葡萄糖苷（Glc）），可以增强磁共振成像（MRI） ）用于癌症治疗。在靶向分子的指导下，Fe ₃O ₄ @ Au-HPG-Glc纳米探针可以精确地靶向肿瘤细胞。在交变磁场（AMF）下，花状Fe ₃ O ₄@ Au-HPG-Glc纳米探针可以沿着核的中心轴旋转，从而通过破坏细胞核或细胞膜来实质上破坏肿瘤细胞。我们的结果表明，这种基于形状依赖性治疗剂的策略对MRI引导的肿瘤治疗具有显着的疗效。此外，与空白组中的抑制水平相比，在治疗的第十二天，荷瘤小鼠中对肿瘤生长的抑制高达约47.3％。与其他已报道的癌症治疗方法不同，我们提出的依赖AMF的靶向癌症治疗是一种新颖的策略，可以潜在地降低胃肿瘤的耐药性。