Abstract The cell possesses the remarkable ability to perceive and process chemical and physical stimuli, which in turn modulate cellular behavior. One of the great wonders about nanotechnology is that it enables the fabrication of tools on the same length scale as biomolecules, thereby providing us with a unique handle for characterizing and controlling basic cellular processes. Owing to their tunable size and shape dependent physical properties, biocompatibility and facile surface modification, gold nanoparticles become potentially powerful tools to probe fundamental aspects of cell biology. Consequently, innovative approaches based on gold nanoparticles are under development toward the manipulation of cell function and improvement of techniques currently used in biomedicine and biotechnology. In this review we provide an overview of recent applications based on gold nanoparticles and nanostructured materials for the modulation of cellular activity and behavior, mediated by their interactions with cell surface receptors.

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用于调节细胞功能和行为的金纳米粒子

摘要 细胞具有显着的感知和处理化学和物理刺激的能力，进而调节细胞行为。纳米技术的一大奇迹是它能够制造与生物分子长度相同的工具，从而为我们提供了一种独特的手段来表征和控制基本的细胞过程。由于其可调节的尺寸和形状依赖于物理特性、生物相容性和容易的表面改性，金纳米粒子成为探测细胞生物学基本方面的潜在有力工具。因此，正在开发基于金纳米粒子的创新方法来操纵细胞功能和改进目前在生物医学和生物技术中使用的技术。