Uterine fibroids (myomas or leiomyomas) are common benign tumors of reproductive aged women. Fibroids are clinically apparent in 20–50% of women, and cause abnormal uterine bleeding, abdominal pain and discomfort, pregnancy complications and infertility. Unfortunately, limited numbers of medical treatment are available but no effective preventive strategies exist. Moreover, the benefits of medical treatments are tempered by lack of efficacy or serious adverse side effects. Fibrosis has recently been recognized as a key pathological event in leiomyoma development and growth. It is defined by the excessive deposition of extracellular matrix (ECM). ECM plays important role in making bulk structure of leiomyoma, and ECM-rich rigid structure is believed to be a cause of abnormal bleeding and pelvic pain/pressure. Dietary phytochemicals are known to regulate fibrotic process in different biological systems, and being considered as potential tool to manage human health. At present, very few dietary phytochemicals have been studied in uterine leiomyoma, and they are mostly known for their antiproliferative effects. Therefore, in this review, our aim was to introduce some dietary phytochemicals that could target fibrotic processes in leiomyoma. Thus, this review could serve as useful resource to develop antifibrotic drugs for possible prevention and treatment of uterine fibroids.

子宫肌瘤（肌瘤或平滑肌瘤）是育龄妇女的常见良性肿瘤。肌瘤在20-50％的女性中临床上很明显，并会导致异常子宫出血，腹痛和不适，怀孕并发症和不孕。不幸的是，可用的治疗方法有限，但是没有有效的预防策略。此外，由于缺乏功效或严重的不良副作用而削弱了药物治疗的益处。纤维化最近被认为是平滑肌瘤发生和发展的关键病理事件。它是由细胞外基质（ECM）的过度沉积所定义的。ECM在制造平滑肌瘤的整体结构中起着重要作用，而富含ECM的刚性结构被认为是异常出血和骨盆疼痛/压力的原因。饮食中的植物化学物质可调节不同生物系统中的纤维化过程，并被认为是管理人类健康的潜在工具。目前，在子宫平滑肌瘤中很少研究饮食中的植物化学物质，并且它们以其抗增殖作用而闻名。因此，在这篇综述中，我们的目的是介绍一些可能针对平滑肌瘤纤维化过程的饮食植物化学物质。因此，本综述可作为开发抗纤维化药物以预防和治疗子宫肌瘤的有用资源。在这篇综述中，我们的目的是介绍一些可以针对平滑肌瘤纤维化过程的饮食植物化学物质。因此，本综述可作为开发抗纤维化药物以预防和治疗子宫肌瘤的有用资源。在这篇综述中，我们的目的是介绍一些可以针对平滑肌瘤纤维化过程的饮食植物化学物质。因此，本综述可作为开发抗纤维化药物以预防和治疗子宫肌瘤的有用资源。