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Nucleic Acid–Based Nanodevices in Biological Imaging
Annual Review of Biochemistry ( IF 12.1 ) Pub Date : 2016-06-13 00:00:00 , DOI: 10.1146/annurev-biochem-060815-014244
Kasturi Chakraborty 1 , Aneesh T. Veetil 1 , Samie R. Jaffrey 2 , Yamuna Krishnan 1, 3
Affiliation  

The nanoscale engineering of nucleic acids has led to exciting molecular technologies for high-end biological imaging. The predictable base pairing, high programmability, and superior new chemical and biological methods used to access nucleic acids with diverse lengths and in high purity, coupled with computational tools for their design, have allowed the creation of a stunning diversity of nucleic acid–based nanodevices. Given their biological origin, such synthetic devices have a tremendous capacity to interface with the biological world, and this capacity lies at the heart of several nucleic acid–based technologies that are finding applications in biological systems. We discuss these diverse applications and emphasize the advantage, in terms of physicochemical properties, that the nucleic acid scaffold brings to these contexts. As our ability to engineer this versatile scaffold increases, its applications in structural, cellular, and organismal biology are clearly poised to massively expand.

中文翻译:


生物成像中基于核酸的纳米器件

核酸的纳米级工程导致了用于高端生物成像的令人兴奋的分子技术。可预测的碱基配对,高可编程性以及用于获得各种长度和高纯度核酸的卓越的新化学和生物学方法,再加上用于其设计的计算工具,已经创造了令人惊叹的基于核酸的纳米器件多样性。考虑到它们的生物学起源,这种合成装置具有与生物界相接的巨大能力,而这种能力是在生物系统中发现应用的几种基于核酸的技术的核心。我们讨论了这些不同的应用,并着重指出了核酸支架在物理化学性质方面的优势。

更新日期:2016-06-13
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