Wearable bioelectronics represents a significant breakthrough in healthcare settings, particularly in (bio)sensing which offers an alternative way to track individual health for diagnostics and therapy. However, there has been no notable improvement in the field of cancer, particularly for skin cancer. Here, we established a wearable bioelectronic patch for transdermal sensing of the melanoma biomarker, tyrosinase (Tyr), using a microneedle array integrated with a surface‐bound chemo‐responsive smart probe to enable target‐specific electrochemical detection of Tyr directly from human skin tissue. The results presented herein demonstrated the feasibility of a transdermal microneedle sensor for direct quantification of enzyme biomarkers in an ex vivo skin model. Initial performance analysis of the transdermal microneedle sensor proved that the designed methodology could be an alternative for fast and reliable diagnosis of melanoma and the evaluation of skin moles. The innovative approach presented here might revolutionize the landscape of skin monitoring by offering a non‐disruptive means for continuous surveillance and timely intervention of skin anomalies such as inflammatory skin diseases or allergies and can be extended to the screening of multiple responses of complementary biomarkers with simple modification in device design.This article is protected by copyright. All rights reserved

中文翻译：

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化学响应探针改良表皮微针贴片在人体皮肤组织中实现酶生物标志物的透皮传感

可穿戴生物电子学代表了医疗保健领域的重大突破，特别是在（生物）传感领域，它为跟踪个人健康状况以进行诊断和治疗提供了另一种方法。然而，在癌症领域，特别是皮肤癌领域，却没有显着的改善。在这里，我们建立了一种可穿戴生物电子贴片，用于黑色素瘤生物标志物酪氨酸酶 (Tyr) 的透皮传感，使用与表面结合化学响应智能探针集成的微针阵列，以实现直接从人体皮肤组织中对 Tyr 进行目标特异性电化学检测。本文提出的结果证明了透皮微针传感器用于直接定量离体皮肤模型中酶生物标志物的可行性。透皮微针传感器的初步性能分析证明，所设计的方法可以成为快速可靠的黑色素瘤诊断和皮肤痣评估的替代方法。这里提出的创新方法可能会彻底改变皮肤监测的格局，通过提供一种不间断的方式来持续监测和及时干预皮肤异常（例如炎症性皮肤病或过敏），并且可以扩展到通过简单的操作筛选补充生物标志物的多种反应。设备设计的修改。本文受版权保护。版权所有