The nuclear pore complex of eukaryotic cells senses the mechanical directionality of translocating proteins, favouring the passage of those that have a leading mechanically labile region. Adding an unstructured, mechanically weak peptide tag to a translocating protein increases its rate of nuclear import and accumulation, suggesting a biotechnological strategy to enhance the delivery of molecular cargos into the cell nucleus.

中文翻译：

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核细胞质蛋白质运输的机械不对称性

真核细胞的核孔复合体感知易位蛋白质的机械方向性，有利于那些具有领先的机械不稳定区域的蛋白质的通过。在易位蛋白中添加非结构化、机械弱的肽标签可以增加其核输入和积累的速率，这表明了一种增强分子货物向细胞核的递送的生物技术策略。