Microplastics (MPs) waste is widespread globally in water systems. The opportunistic human pathogen can cause serious acute and chronic infections that are notoriously difficult to treat. Ciprofloxacin (CIP) is broadly applied as an anti- drug. A growing evidence reveals that antibiotic-resistance genes-carrying were detected on MPs forming plastisphere due to their adsorbability along with high occurrence of CIP in water environments. The MPs-niched CIP-resistant has been likely to emerge as an unignorable public health issue. Here, we offered a novel approach to assess the development of CIP-resistant under MPs-antibiotic coexistence at a water region scale. By combing the adsorption isotherm models used to estimate CIP condensation around MPs and a pharmacokinetic/pharmacodynamic-based microbial population dynamic model, we predicted the development on CIP-adsorbed MPs in waters. Our assessment revealed a high antibiotic resistance in the populations (∼50 %) with a wider range of waterborne total cell counts (∼10–10 cfu mL) among water regions in that the resistance proportion was primarily determined by CIP pollution level and relative abundance of various polymer type of MPs. We implicate that water region-specific MPs were highly likely to provide media for propagation. Our results highlight the importance of antibiotic-resistant pathogen colonization−emerging environmental medium interactions when addressing global threat from MPs pollution, in the context of MPs-antibiotics co-contamination assessment and for the continued provision of water system management.

中文翻译：

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在水域范围内评估微塑料-抗生素共存诱导的耐环丙沙星铜绿假单胞菌


微塑料 (MP) 废物在全球水系统中广泛存在。机会性人类病原体可引起严重的急性和慢性感染，且众所周知难以治疗。环丙沙星（CIP）作为抗药物被广泛应用。越来越多的证据表明，由于其吸附性以及水环境中 CIP 的高发生率，在形成塑料球的 MP 上检测到携带抗生素抗性基因。国会议员对 CIP 的抵制可能会成为一个不可忽视的公共卫生问题。在这里，我们提供了一种新方法来评估水区范围内 MPs 与抗生素共存下 CIP 耐药性的发展。通过结合用于估计 MP 周围 CIP 冷凝的吸附等温线模型和基于药代动力学/药效动力学的微生物种群动态模型，我们预测了水中 CIP 吸附 MP 的发展。我们的评估显示，水域中水性总细胞计数范围较大（～10-10 cfu mL）的人群具有较高的抗生素耐药性（∼50%），因为耐药性比例主要由 CIP 污染水平和相对丰度决定各种聚合物类型的MP。我们暗示特定水域的议员很可能为传播提供媒介。我们的结果强调了在解决 MPs 污染的全球威胁时、在 MPs-抗生素共同污染评估和持续提供水系统管理的背景下，抗生素抗性病原体定植与新兴环境介质相互作用的重要性。