The toxicity for the human body of non-steroidal anti-inflammatory drugs (NSAIDs) overdoses is a consequence of their low water solubility, high doses, and facile accessibility to the population. New drug delivery systems (DDS) are necessary to overcome the bioavailability and toxicity related to NSAIDs. In this context, UiO-66(Zr) metal-organic framework (MOF) shows high porosity, stability, and load capacity, thus being a promising DDS. However, the adsorption and release capability for different NSAIDs is scarcely described. In this work, the biocompatible UiO-66(Zr) MOF was used to study the adsorption and release conditions of ibuprofen, naproxen, and diclofenac using a theoretical and experimental approximation. DFT results showed that the MOF-drug interaction was due to an intermolecular hydrogen bond between protons of the groups in the defect sites, (μ − OH, and − OH) and a lone pair of oxygen carboxyl functional group of the NSAIDs. Also, the experimental results suggest that the solvent where the drug is dissolved affects the adsorption process. The adsorption kinetics are similar between the drugs, but the maximum load capacity differs for each drug. The release kinetics assay showed a solvent dependence kinetics whose maximum liberation capacity is affected by the interaction between the drug and the material. Finally, the biological assays show that none of the systems studied are cytotoxic for HMVEC. Additionally, the wound healing assay suggests that the UiO-66(Zr) material has potential application on the wound healing process. However, further studies should be done.

中文翻译：

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UiO-66(Zr)作为非甾体抗炎药的给药系统

非甾体类抗炎药 (NSAID) 过量服用对人体的毒性是由于其水溶性低、剂量高且易于人群获取的结果。新的药物输送系统（DDS）对于克服与非甾体抗炎药相关的生物利用度和毒性是必要的。在这种背景下，UiO-66(Zr)金属有机骨架(MOF)表现出高孔隙率、稳定性和负载能力，因此是一种有前途的DDS。然而，不同 NSAID 的吸附和释放能力却很少被描述。在这项工作中，生物相容性 UiO-66(Zr) MOF 用于通过理论和实验近似研究布洛芬、萘普生和双氯芬酸的吸附和释放条件。 DFT 结果表明，MOF-药物相互作用是由于缺陷位点（μ - OH 和 - OH）基团的质子与 NSAID 的孤对氧羧基官能团之间的分子间氢键所致。此外，实验结果表明溶解药物的溶剂会影响吸附过程。药物之间的吸附动力学相似，但每种药物的最大负载能力不同。释放动力学测定显示出溶剂依赖性动力学，其最大释放能力受到药物和材料之间的相互作用的影响。最后，生物测定表明所研究的系统均不具有 HMVEC 细胞毒性。此外，伤口愈合试验表明UiO-66(Zr)材料在伤口愈合过程中具有潜在的应用。然而，还应该进行进一步的研究。