A one‐pot multi‐component reaction strategy for the selective synthesis of 5‐trifluoromethyl pyrimidine derivatives has been established. This method avoids the inherent selectivity challenges in direct pyrimidine trifluoromethylation. The reaction demonstrates tolerance to various functional groups, yielding 5‐trifluoromethyl pyrimidine derivatives with up to 80% yields. Moreover, the practicality of this method has been underscored through scale‐up reactions.

中文翻译：

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一锅法多组分选择性合成5-三氟甲基嘧啶衍生物

建立了选择性合成5-三氟甲基嘧啶衍生物的一锅多组分反应策略。该方法避免了直接嘧啶三氟甲基化中固有的选择性挑战。该反应表现出对各种官能团的耐受性，产生 5-三氟甲基嘧啶衍生物，产率高达 80%。此外，该方法的实用性通过放大反应得到了强调。