The replicational age of single cells provides a temporal reference for tracking cell fate transition trajectories. The computational framework EpiTrace measures cell age using single-cell ATAC-seq data, specifically by considering chromatin accessibility at clock-like genomic loci, enabling the reconstruction of the history of developmental and pathological processes.

中文翻译：

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从单细胞 ATAC-seq 数据解码细胞复制年龄

单细胞的复制年龄为追踪细胞命运转变轨迹提供了时间参考。计算框架 EpiTrace 使用单细胞 ATAC-seq 数据测量细胞年龄，特别是通过考虑类似时钟基因组位点的染色质可及性，从而能够重建发育和病理过程的历史。