Amide bond is not only the building block of proteins, peptides, and some synthetic polymers but is also commonly found in drugs, materials, and insecticides. Moreover, amides are vital intermediates for the synthesis of other types of molecules, including amines, isonitriles, and -heterocycles. Nowadays, many techniques have been established for the synthesis of amide bonds, however, the majority of them depend on coupling reagents and an excess amount of base to neutralize the acids produced during the reaction. These methods are not only costly but also produce waste which is harmful to the environment. Due to the significance of amides, the development of methods for constructing amide bonds remains one of the most important tasks of organic synthesis. To develop green and sustainable routes for the preparation of amides, as well as to optimize conventional synthesis methods, more and more attention is being paid to the development of new synthetic routes using highly active intermediates generated by electrochemistry. The use of sustainable electricity to substitute chemical reagents is environmentally benign and would also establish new alternative synthetic routes. The purpose of this review is to demonstrate the continuous applications of electrosynthesis in the preparation of amides through relevant works reported from 2018 to the present.

中文翻译：

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酰胺电合成：2018年以来的成果与展望


酰胺键不仅是蛋白质、肽和一些合成聚合物的组成部分，而且也常见于药物、材料和杀虫剂中。此外，酰胺是合成其他类型分子（包括胺、异腈和杂环）的重要中间体。如今，已经建立了许多用于合成酰胺键的技术，然而，其中大多数依赖于偶联剂和过量的碱来中和反应过程中产生的酸。这些方法不仅成本高昂，而且会产生对环境有害的废物。由于酰胺的重要性，开发构建酰胺键的方法仍然是有机合成最重要的任务之一。为了开发绿色和可持续的酰胺制备路线，以及优化传统合成方法，利用电化学产生的高活性中间体开发新的合成路线越来越受到关注。使用可持续电力替代化学试剂对环境无害，并且还将建立新的替代合成路线。本综述的目的是通过2018年至今报道的相关工作来论证电合成在酰胺制备中的持续应用。