Air pollutants deteriorate the survival environment and endanger human health around the world. A large number of studies have confirmed that air pollution jeopardizes multiple organs, such as the cardiovascular, respiratory, and central nervous systems. Skin is the largest organ and the first barrier that protects us from the outside world. Air pollutants such as particulate matter (PM), polycyclic aromatic hydrocarbons (PAHs), volatile organic compounds (VOCs) will affect the structure and function of the skin and bring about the development of inflammatory skin diseases (atopic dermatitis (AD), psoriasis), skin accessory diseases (acne, alopecia), auto-immune skin diseases (cutaneous lupus erythematosus(CLE) scleroderma), and even skin tumors (melanoma, basal cell carcinoma (BCC), squamous-cell carcinoma (SCC)). Oxidative stress, skin barrier damage, microbiome dysbiosis, and skin inflammation are the pathogenesis of air pollution stimulation. In this review, we summarize the current evidence on the effects of air pollution on skin diseases and possible mechanisms to provide strategies for future research.

中文翻译：

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空气污染与皮肤病：相关机制的综合评价


空气污染物恶化了世界各地的生存环境，危害人类健康。大量研究证实，空气污染会危害多个器官，如心血管、呼吸和中枢神经系统。皮肤是最大的器官，也是保护我们免受外界侵害的第一道屏障。空气污染物如颗粒物（PM）、多环芳烃（PAHs）、挥发性有机化合物（VOCs）等会影响皮肤的结构和功能，引发炎症性皮肤病（特应性皮炎（AD）、牛皮癣） 、皮肤附属疾病（痤疮、脱发）、自身免疫性皮肤病（皮肤红斑狼疮（CLE）硬皮病），甚至皮肤肿瘤（黑色素瘤、基底细胞癌（BCC）、鳞状细胞癌（SCC））。氧化应激、皮肤屏障损伤、微生物群失调和皮肤炎症是空气污染刺激的发病机制。在这篇综述中，我们总结了有关空气污染对皮肤病影响的现有证据以及可能的机制，为未来的研究提供策略。