Axially chiral cycloalkylidenes are interesting but less developedaxially chiral molecules. Here, a bispidine‐based chiral amine catalytic system was developed to promote efficiently the asymmetric Knoevenagel condensation ofN‐protected oxindoles and benzofuranones with 4‐substituted cyclohexanones. A variety of alkylidenecycloalkanes with stable axial chirality were obtained in good yields with high er. Based on the absolute configuration determination of product and DFT calculations, a possible mechanism of stereoselective induction was proposed.

中文翻译：

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催化不对称诺文格尔缩合反应生成稳定的轴向手性亚环己基

轴向手性亚环烷基是有趣的，但尚未开发的轴向手性分子。在此，开发了一种基于双吡啶的手性胺催化体系，以有效促进 N 保护的羟吲哚和苯并呋喃酮与 4-取代环己酮的不对称 Knoevenagel 缩合。多种具有稳定轴向手性的亚烷基环烷烃以良好的产率和较高的er得到。基于产物的绝对构型测定和DFT计算，提出了立体选择性诱导的可能机制。