Circular polarization-resolved Raman scattering methods include Raman optical activity (ROA) and its derivative─surface-enhanced Raman optical activity (SEROA). These spectroscopic modalities are rapidly developing due to their high information content, stand-off capabilities, and rapid development of Raman-active chiral nanostructures. These methods enable a direct readout of the vibrational energy levels of chiral molecules, crystals, and nanostructured materials, making it possible to study complex interactions and the dynamic interfaces between them. They were shown to be particularly valuable for nano- and biotechnological fields encompassing complex particles with nanoscale chirality that combine strong scattering and intense polarization rotation. This perspective dives into recent advancements in ROA and SEROA, their distinction from surface-enhanced Raman scattering, and the potential of these information-rich label-free spectroscopies for the detection of chiral biomolecules.

中文翻译：

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圆偏振分辨拉曼光学活性：振动态手性光谱的视角


圆偏振分辨拉曼散射方法包括拉曼旋光性（ROA）及其衍生物——表面增强拉曼旋光性（SEROA）。这些光谱模式由于其高信息含量、隔离能力以及拉曼活性手性纳米结构的快速发展而正在迅速发展。这些方法可以直接读出手性分子、晶体和纳米结构材料的振动能级，从而可以研究复杂的相互作用以及它们之间的动态界面。它们被证明对于纳米和生物技术领域特别有价值，这些领域包含具有纳米级手性的复杂粒子，结合了强散射和强烈的偏振旋转。该观点深入探讨了 ROA 和 SEROA 的最新进展、它们与表面增强拉曼散射的区别，以及这些信息丰富的无标记光谱用于检测手性生物分子的潜力。